Searchable abstracts of presentations at key conferences in endocrinology

ea0035p956 | Steroid metabolism and action | ECE2014

Profiling of neuroactive steroids, their precursors and metabolites in patients suffering from multiple sclerosis

Kancheva Radmila , Hill Martin , Kancheva Lyudmila , Velikova Marta , Pavelcova Miluse , Starka Luboslav , Havrdova Eva

Some steroids modulate the permeability of ionotropic receptors on cell membranes and therefore may activate or inhibit neuronal activity depending on the steroid structure. These neuroactive steroids (NAS) exert neuroprotective effects like the neuronal remyelination.Multiple sclerosis (MS) is the most common cause of neurological disability in young adults. Therefore, the authors have followed the neuroprotective, GABAergic, glycinergic, glutamatergic ...